Which of the following is a pharmacologic treatment option for osteoarthritis?

All of the listed options—acetaminophen, topical capsaicin, and duloxetine—are recognized pharmacologic treatment options for osteoarthritis, making the selection accurate.

Acetaminophen is often recommended as a first-line therapy for osteoarthritis pain management due to its analgesic properties. It is generally considered safe and effective for mild to moderate pain, though it does not possess anti-inflammatory effects.

Topical capsaicin is used as a local treatment for osteoarthritis, particularly for knee osteoarthritis. Capsaicin works by depleting substance P, a pain neurotransmitter, from nerve endings, thereby reducing the sensation of pain upon application to the affected area.

Duloxetine is an antidepressant that has also been shown to be effective in managing chronic pain, including pain associated with osteoarthritis. It works by inhibiting the reuptake of serotonin and norepinephrine, which can help alleviate pain perception.

Since each of these medications plays a role in the treatment of osteoarthritis, the correct answer reflects the comprehensive nature of pharmacologic approaches available in managing this condition.