Which of the following is NOT considered a DMARD?

In the context of disease-modifying antirheumatic drugs (DMARDs), the correct choice is prednisone, as it is not classified as a DMARD. DMARDs are a group of medications specifically used to alter the course of autoimmune diseases such as rheumatoid arthritis by targeting the underlying pathophysiology, thereby preventing joint damage and disease progression.

Methotrexate, hydroxychloroquine, and sulfasalazine are all considered DMARDs. Methotrexate is one of the first-line treatments for rheumatoid arthritis, known for its efficacy in slowing disease progression and improving symptoms. Hydroxychloroquine is primarily used in treating lupus and rheumatoid arthritis, also acting to modify the disease course. Sulfasalazine is used for inflammatory bowel disease and rheumatoid arthritis, functioning similarly to other DMARDs.

In contrast, prednisone is a corticosteroid that is utilized primarily for its anti-inflammatory properties, providing rapid relief of symptoms. However, it does not modify the disease process and is thus not included in the category of DMARDs. Prednisone is often used in conjunction with DMARDs for symptom management during flares or for acute disease exacerbations but does not have the same long-term disease-altering effects.