Which medication is commonly recommended for managing acute lower back pain?

Acetaminophen is commonly recommended for managing acute lower back pain due to its effectiveness in relieving mild to moderate pain. It acts primarily as an analgesic and antipyretic, helping to reduce discomfort without the anti-inflammatory properties associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its use is especially relevant in cases where patients may have contraindications for NSAIDs, such as gastrointestinal issues, kidney problems, or other concerns that make traditional anti-inflammatory treatments less viable.

While other medications may be utilized in specific scenarios—such as opioids for severe pain or antidepressants for chronic conditions—acetaminophen remains a first-line option for acute episodes because it is generally safe, well-tolerated, and has a lower risk for dependency compared to opioids. Additionally, guidelines often emphasize starting with non-pharmacologic treatments and simple analgesics like acetaminophen before escalating to more complex medication regimens.