What is the first-line medication and dosage for uncomplicated cellulitis?

For uncomplicated cellulitis, Keflex (cephalexin) is the recommended first-line oral antibiotic. The standard dosage of 500mg taken four times a day (QID) for a duration of 5 to 7 days is effective in treating the most common pathogens associated with this skin infection, primarily Streptococcus and Staphylococcus bacteria.

Cellulitis typically occurs when bacteria enter through a break in the skin, and antibiotic treatment is aimed at eradicating these organisms. Keflex is a first-generation cephalosporin, which has good activity against Gram-positive cocci and is well-absorbed when taken orally. Its dosing schedule allows for adequate plasma concentration to effectively combat the infection throughout the day.

While other options mentioned might have efficacy for certain types of infections, they are not ideal for uncomplicated cellulitis. For example, Amoxicillin is often insufficient alone for skin infections due to resistance patterns. Doxycycline, while useful for certain skin infections, is mainly indicated for conditions like acne and infections caused by atypical organisms or resistant strains. Vancomycin, although an important antibiotic for resistant Gram-positive infections, is typically reserved for more severe or complicated cases of cellulitis and not for uncomplicated presentations. Thus,