What are the two most commonly affected joints in pseudogout?

Pseudogout, clinically known as calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, typically causes acute inflammatory arthritis that affects specific joints in the body. The two joints most commonly affected in pseudogout are the knees and wrists.

The knee is often the primary joint involved due to its structure and the prevalence of calcium pyrophosphate crystals in the synovial fluid, which can lead to acute episodes of swelling, pain, and redness. Similarly, the wrist may also be affected, making it a common site for the condition as well. This preference for larger joints like the knee, along with involvement of the wrist, is characteristic of pseudogout.

Other options such as the ankle and elbow, shoulders and hips, and feet and hands do not typically reflect the most common sites of symptomatic presentations, thus aligning with the correct answer focusing on knees and wrists. Understanding this pattern is crucial for diagnosis and management of pseudogout in clinical practice.