What are the first-line antibiotics for treating uncomplicated acute cystitis in nonpregnant adult females?

The first-line antibiotics for treating uncomplicated acute cystitis in nonpregnant adult females include Macrobid (nitrofurantoin), fosfomycin, and Septra (trimethoprim-sulfamethoxazole). Nitrofurantoin is particularly effective due to its specific action in the urinary tract and is well-tolerated with minimal resistance concerns. Fosfomycin is a single-dose option that is also effective against common uropathogens. Trimethoprim-sulfamethoxazole is widely used due to its efficacy and the ease of a short course treatment.

These choices are preferred based on their effectiveness against the pathogens typically responsible for uncomplicated cystitis, such as Escherichia coli, and their established safety profiles in the appropriate patient population. They also consider resistance patterns, ensuring these options remain effective in treating this condition.