In the case of a first episode of non-provoked seizure, which two investigations should be ordered for outpatient follow-up?

In the context of a first episode of non-provoked seizure, the most appropriate investigations for outpatient follow-up are MRI of the head and an electroencephalogram (EEG).

An MRI is preferred because it provides detailed images of the brain's structure and can help identify any underlying abnormalities, such as tumors, vascular malformations, or structural changes that might be responsible for the seizure. This step is crucial in evaluating the cause of the seizure and determining whether any further intervention or treatment is necessary.

The EEG is essential as it records the electrical activity in the brain and can help in diagnosing seizure types, determining if there is ongoing epileptic activity, and establishing a diagnosis of epilepsy if further episodes occur. EEG findings can also provide insight into the likelihood of future seizures.

These two investigations together offer a comprehensive approach to understanding the underlying causes of the seizure and establishing an appropriate management plan. They are integral to the outpatient follow-up in ensuring that any potential risk for recurrence or underlying pathology is addressed.